Book Santee, SC Vacations

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Santee Travel Guide

Right now's the time to plan your perfect Santee trip. Relax and let the hardworking team at Orbitz find incredible-value flight and hotel combos for you.

Pick out your preferred airfares, hotels, rental cars and experiences to save as much as ! Packaging your bookings is one of the best ways to save.

And it doesn't stop there — if you have no idea who to fly with or where to stay, our ever-expanding database has more than 500,000 accommodation options across the globe and 500 partner airlines. It's your choice!

There are endless options to create your own amazing vacation, whatever your interests, style or budget.

Santee Travel Guide

Where is Santee?

Not sure just where Santee sits on the map?

It's situated in South Carolina, 35 miles from Moncks Corner.

This area of South Carolina is home to about 1,000 people.

Car Rentals in Santee

See the region your own way by checking out car rentals in Santee with Orbitz. Rev up that engine and fasten your seatbelt — it's time to hit the gas!

Where to stay in Santee – Hotel Accommodation

With as few as 11 hotels in Santee, you should book soon! Orbitz has everything you'll need to lock in a comfortable room.

Unsure where to lay your head? Allow us to make things a little easier! Our recommended options are the Holiday Inn Santee and Hampton Inn Santee I-95.

Nearest Airports to Santee

Lay back, whip out your travel pillow and scroll through the inflight movies. Before you know it, you'll be coming in to land at Charleston International Airport (CHS). Sitting 50 miles from the city center, this is Santee's most convenient airport.

Popular Places to Visit Near Santee

Done everything in Santee already? Don't worry! Dalzell is just 35 miles from here and has plenty of activities to keep you busy. Start exploring its culture at the Shaw Air Force Base. If you're itching to find out more, make your way to Sumter Mall and Palmetto Park too. Located 40 miles away, Hanahan is one more favored destination. While you're here, be sure to check out Wannamaker County Park, Whirlin' Waters Adventure Waterpark and the Crowfield Golf Club.

No Cancellation Fees

Do you need to revise or cancel your booking? Nervous about a big fee? You'll be happy to hear that we don't have one!^ Fingers crossed, your selected hotel and airline don't either, but it's a good idea to get in touch with them about their policies.

Top rated hotels for your Santee vacation

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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